Structure of PDB 6i2k Chain A

Receptor sequence
>6i2kA (length=290) Species: 39054 (Enterovirus A71) [Search protein sequence]
GDRVADMIESRALTQALPAPTGQNTQVSSHRLDTGEVPALQAAEIGASSN
TSDESMIETRCVLNSHSTAETTLDSFFSRAGLVGEIDLPLEGTTNPSGYA
NWDIDITGYAQMRRKVELFTYMRFDAEFTFVACTPTGQVVPQLLQYMFVP
PGAPKPESRESLAWQTATNPSVFVKLTDPPAQVSVPFMSPASAYQWFYDG
YPTFGEHKQEKDLEYGACPNNMMGTFSVRTVGSSKSKYALVVRIYMRMKH
VRAWIPRPMRNQNYLFKANPNYAGDSIKPTGTSRNAITTL
3D structure
PDB6i2k Unexpected mode of engagement between enterovirus 71 and its receptor SCARB2.
ChainA
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.4.22.29: picornain 2A.
3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 906 A I111 I113 T114 F135 F155 P177 S178 V179 V192 Y201 Q202 W203 N228 I104 I106 T107 F128 F148 P170 S171 V172 V185 Y194 Q195 W196 N221
External links
PDB RCSB:6i2k, PDBe:6i2k, PDBj:6i2k
PDBsum6i2k
PubMed30531980
UniProtQ66479|POLG_HE71M Genome polyprotein

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