Structure of PDB 6i0p Chain A

Receptor sequence
>6i0pA (length=301) Species: 243274 (Thermotoga maritima MSB8) [Search protein sequence]
HHHMVDEILKLKKEKGYIILAHNFQIPELQDIADFVGDSLQLARKAMELS
EKKILFLGVDFMAELVKILNPDKKVIVPDRSATCPMANRLTPEIIREYRE
KFPDAPVVLYVNSTSECKTLADVICTSANAVEVVKKLDSSVVIFGPDRNL
GEYVAEKTGKKVITIPENGHCPVHQFNAESIDAVRKKYPDAKVIVHPECP
KPVRDKADYVGSTGQMEKIPERDPSRIFVIGTEIGMIHKLKKKFPDREFV
PLEMAVCVNMKKNTLENTLHALQTESFEVILPKEVIEKAKKPILRMFELM
G
3D structure
PDB6i0p Design of specific inhibitors of quinolinate synthase based on [4Fe-4S] cluster coordination.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.72: quinolinate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SF4 A F21 C81 N109 C168 C254 F24 C84 N112 C171 C257
BS02 QAS A H19 F21 D35 S36 M59 N109 H193 S209 T210 H22 F24 D38 S39 M62 N112 H196 S212 T213 PDBbind-CN: -logKd/Ki=4.40,IC50=40uM
Gene Ontology
Molecular Function
GO:0008987 quinolinate synthetase A activity
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0009435 NAD biosynthetic process
GO:0019363 pyridine nucleotide biosynthetic process
GO:0019805 quinolinate biosynthetic process
GO:0034628 'de novo' NAD biosynthetic process from aspartate
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Biological Process
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Cellular Component
External links
PDB RCSB:6i0p, PDBe:6i0p, PDBj:6i0p
PDBsum6i0p
PubMed30855610
UniProtQ9X1X7|NADA_THEMA Quinolinate synthase (Gene Name=nadA)

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