Structure of PDB 6i0o Chain A

Receptor sequence

>6i0oA (length=434) Species: 9606 (Homo sapiens) [Search protein sequence]

SYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKIT
LKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKY
EQGFITDPVVLSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISS
RDIDFLKEEEHDCFLEEIMTKREDLVVAPAGITLKEANEILQRSKKGKLP
IVNEDDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDDKYRL
DLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVIGGNVVTAAQA
KNLIDAGVDALRVGMEVLACGRPQATAVYKVSEYARRFGVPVIADGGIQN
VGHIAKALALGASTVMMGSLLAATTEAPGEYFFSKGSIHKFVPYLIAGIQ
HSCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQV

3D structure

PDB

6i0o A Nucleotide-Dependent Conformational Switch Controls the Polymerization of Human IMP Dehydrogenases to Modulate their Catalytic Activity.

Chain

Resolution

2.623 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.1.1.205: IMP dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	GTP	A	I157 S159 S160 D162 D184 L185 V186 K206 G207	I147 S149 S150 D152 D174 L175 V176 K196 G197
BS02	GTP	A	K109 Y110 Q112 P118 F139 C140 G141 S160 K208 T225 D226 K229	K99 Y100 Q102 P108 F129 C130 G131 S150 K198 T215 D216 K219
BS03	GTP	A	E111 G113 N198 N230 P234 K238 K242	E101 G103 N188 N220 P224 K228 K232

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0003824	catalytic activity
GO:0003938	IMP dehydrogenase activity
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding

	Biological Process
GO:0006164	purine nucleotide biosynthetic process
GO:0006177	GMP biosynthetic process
GO:0006183	GTP biosynthetic process
GO:0007623	circadian rhythm
GO:0046651	lymphocyte proliferation
GO:0071353	cellular response to interleukin-4
GO:0097294	'de novo' XMP biosynthetic process

	Cellular Component
GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005778	peroxisomal membrane
GO:0005829	cytosol
GO:0016020	membrane
GO:0034774	secretory granule lumen
GO:0070062	extracellular exosome
GO:1904813	ficolin-1-rich granule lumen

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:6i0o, PDBe:6i0o, PDBj:6i0o
PDBsum	6i0o
PubMed	30664871
UniProt	P12268\|IMDH2_HUMAN Inosine-5'-monophosphate dehydrogenase 2 (Gene Name=IMPDH2)

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