Structure of PDB 6hzv Chain A

Receptor sequence
>6hzvA (length=266) Species: 9606 (Homo sapiens) [Search protein sequence]
TIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQGPDQQR
DFQREIQILKALHSDFIVKYRGVSYQSLRLVMEYLPSGCLRDFLQRHRAR
LDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGL
AKLLPLDKDYYVVRPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCD
KSCSPSAEFLRMPALSRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSP
QDRPSFSALGPQLDML
3D structure
PDB6hzv Identification of 2-Imidazopyridine and 2-Aminopyridone Purinones as Potent Pan-Janus Kinase (JAK) Inhibitors for the Inhaled Treatment of Respiratory Diseases.
ChainA
Resolution2.46 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D949 R953 N954 D967
Catalytic site (residue number reindexed from 1) D129 R133 N134 D147
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GYW A L828 A853 V884 M902 Y904 L905 G908 C909 D912 R953 L956 L14 A39 V68 M82 Y84 L85 G88 C89 D92 R133 L136 MOAD: ic50=59nM
PDBbind-CN: -logKd/Ki=8.22,IC50=6nM
BindingDB: IC50=59nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6hzv, PDBe:6hzv, PDBj:6hzv
PDBsum6hzv
PubMed31609613
UniProtP52333|JAK3_HUMAN Tyrosine-protein kinase JAK3 (Gene Name=JAK3)

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