Structure of PDB 6hzn Chain A

Receptor sequence
>6hznA (length=743) Species: 9606 (Homo sapiens) [Search protein sequence]
ITDENPEVMIPFTNANYDSHPMLYFSRAEVAELQLRAASSHEHIAARLTE
AVHTMLSSPLEYLPPWDPKDYSARWNEIFGNNLGALAMFCVLYPENIEAR
DMAKDYMERMAAQPSWLVKDAPWDEVPLAHSLVGFATAYDFLYNYLSKTQ
QEKFLEVIANASGYMYETSYRRGWGFQYLHNHQPTNCMALLTGSLVLMNQ
GYLQEAYLWTKQVLTIMEKSLVLLREVTDGSLYEGVAYGSYTTRSLFQYM
FLVQRHFNINHFGHPWLKQHFAFMYRTILPGFQRTVAIADSNYNWFYGPE
SQLVFLDKFVMRNGSGNWLADQIRRNRVVEGPGTPSKGQRWCTLHTEFLW
YDGSLKSVPPPDFGTPTLHYFEDWGVVTYGSALPAEINRSFLSFKSGKLG
GRAIYDIVHRNKYKDWIKGWRNFNAGHEHPDQNSFTFAPNGVPFITEALY
GPKYTFFNNVLMFSPAVSKSCFSPWVGQVTEDCSSKWSKYKHDLAASCQG
RVVAAEEKNGVVFIRGEGVGAYNPQLNLKNVQRNLILLHPQLLLLVDQIH
LGEESPLETAASFFHNVDVPFEETVVDGVHGAFIRQRDGLYKMYWMDDTG
YSEKATFASVTYPRGYPYNGTNYVNVTMHLRSPITRAAYLFIGPSIDVQS
FTVHGDSQQLDVFIATSKHAYATYLWTGEATGQSAFAQVIADRHKILFDR
NSAIKSSIVPEVKDYAAIVEQNLQHFKPVFQLLEKQILSRVRN
3D structure
PDB6hzn The structure of human dermatan sulfate epimerase 1 emphasizes the importance of C5-epimerization of glucuronic acid in higher organisms
ChainA
Resolution2.41 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 5.1.3.19: chondroitin-glucuronate 5-epimerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A H452 E470 N481 H429 E447 N458
External links
PDB RCSB:6hzn, PDBe:6hzn, PDBj:6hzn
PDBsum6hzn
PubMed
UniProtQ9UL01|DSE_HUMAN Dermatan-sulfate epimerase (Gene Name=DSE)

[Back to BioLiP]