Structure of PDB 6hyj Chain A

Receptor sequence
>6hyjA (length=221) Species: 9606 (Homo sapiens) [Search protein sequence]
HSELRKLFYSADAVCFDVDSTVIREEGIDELAKICGVEDAVSEMTRRAMG
GAVPFKAALTERLALIQPSREQVQRLIAEQPPHLTPGIRELVSRLQERNV
QVFLISGGFRSIVEHVASKLNIPATNVFANRLKFYFNGEYAGFDETQPTA
ESGGKGKVIKLLKEKFHFKKIIMIGDGATDMEACPPADAFIGFGGNVIRQ
QVKDNAKWYITDFVELLGELE
3D structure
PDB6hyj Crystal structures and snapshots along the reaction pathway of human phosphoserine phosphatase.
ChainA
Resolution1.929 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.3: phosphoserine phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SEP A D20 M52 G110 K158 T182 D17 M49 G107 K155 T179
BS02 CA A D20 D22 D179 D17 D19 D176
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0016787 hydrolase activity
GO:0036424 L-phosphoserine phosphatase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0001701 in utero embryonic development
GO:0006563 L-serine metabolic process
GO:0006564 L-serine biosynthetic process
GO:0009612 response to mechanical stimulus
GO:0031667 response to nutrient levels
GO:0033574 response to testosterone
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:6hyj, PDBe:6hyj, PDBj:6hyj
PDBsum6hyj
PubMed31205021
UniProtP78330|SERB_HUMAN Phosphoserine phosphatase (Gene Name=PSPH)

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