Structure of PDB 6hxs Chain A

Receptor sequence
>6hxsA (length=248) Species: 9606 (Homo sapiens) [Search protein sequence]
SMGWAAAREAAGRDMLAADLRCSLFASALQSYKRDSVLRPFPASYARGDC
KDFEALLADASKLPNLKELLQSSGDNHKRAWDLVSWILSSKVLTIHSAGK
AEFEKIQKLTGAPHTPVPAPDFLFEIEYFDPANAKFYETKGERDLIYAFH
GSRLENFHSIIHNGLHCHLNKTSLFGEGTYLTSDLSLALIYSPHGHGWQH
SLLGPILSCVAVCEVIDHPDVKCIPPKYFVVTNNQLLRVKYLLVYSQK
3D structure
PDB6hxs Human PARP16 (ARTD15) IN COMPLEX WITH CARBA-NAD
ChainA
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CNA A H152 G153 S154 N158 S161 I162 L167 H168 H170 F177 Y182 Y193 Y254 H150 G151 S152 N156 S159 I160 L165 H166 H168 F175 Y180 Y191 Y228
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:6hxs, PDBe:6hxs, PDBj:6hxs
PDBsum6hxs
PubMed
UniProtQ8N5Y8|PAR16_HUMAN Protein mono-ADP-ribosyltransferase PARP16 (Gene Name=PARP16)

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