Structure of PDB 6hxb Chain A

Receptor sequence
>6hxbA (length=968) Species: 9823 (Sus scrofa) [Search protein sequence]
ENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELELVIEQFEDL
LVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQER
NAENAIEALKEYEPEMGKVYRQDSVQRIKAKDIVPGDIVEIAVGDKVPAD
IRLTSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGT
NIAAGKAMGVVVATGVNTEIGKIRDEERTPLQQKLDEFGEQLSKVISLIC
IAVWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTC
LALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFI
LDKVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVKCHQYDGLVELATICA
LCNDSDYNEAKGVYEKVGEATETALTCLVEKMNVFDTELKGLSKIERANA
CNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPKMFVKGAPEGVIDRCTH
IRVGSTKVPMTPGVKQKIMSVIREWGSGSDTLRCLALATHDNPMRREEMN
LEDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGD
NKGTAVAICRRIGIFGQDEDVTSKAFTGREFDELNPSAQREACLNARCFA
RVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKSEIGIAMGSGTAVA
KTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFL
TAALGFPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEP
LISGWLFFRYLAIGCYVGAATVGAAAWWFIAADGGPRVTFYQLSHFLQCK
EDNPDFEGVDCAVFESPYPMTMALSVLVTIEMCNALNSLSENQSLLRMPP
WENIWLVGSICLSMSLHFLILYVEPLPLIFQITPLNLTQWLMVLKISLPV
ILMDETLKFVARNYLEPA
3D structure
PDB6hxb Structures of the heart specific SERCA2a Ca 2+ -ATPase.
ChainA
Resolution4.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.2.2.10: P-type Ca(2+) transporter.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A N767 E770 T798 D799 N741 E744 T772 D773
BS02 CA A V304 A305 A306 I307 E309 N795 D799 V286 A287 A288 I289 E291 N769 D773
BS03 CA A D351 T353 D702 D333 T335 D676
BS04 ACP A D351 T353 F487 R489 K492 K514 G515 R677 N705 D333 T335 F467 R469 K472 K488 G489 R651 N679
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0005215 transporter activity
GO:0005388 P-type calcium transporter activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0046872 metal ion binding
GO:0086039 P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential
Biological Process
GO:0000045 autophagosome assembly
GO:0006816 calcium ion transport
GO:0006874 intracellular calcium ion homeostasis
GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling
GO:0016240 autophagosome membrane docking
GO:0070588 calcium ion transmembrane transport
GO:0086036 regulation of cardiac muscle cell membrane potential
GO:0140056 organelle localization by membrane tethering
GO:1990456 mitochondrion-endoplasmic reticulum membrane tethering
Cellular Component
GO:0016020 membrane
GO:0016529 sarcoplasmic reticulum
GO:0033017 sarcoplasmic reticulum membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6hxb, PDBe:6hxb, PDBj:6hxb
PDBsum6hxb
PubMed30777856
UniProtP11607|AT2A2_PIG Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (Gene Name=ATP2A2)

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