Structure of PDB 6hx1 Chain A

Receptor sequence
>6hx1A (length=387) Species: 9606 (Homo sapiens) [Search protein sequence]
SVVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPECFRESDE
HPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLQQ
TTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKVGRH
SFSRRSGVPGTEGWIAPEMLSENPTYTVDIFSAGCVFYYVISEGSHPFGK
SLQRQANILLGACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVL
KHPFFWSLEKQLQFFQDVSDRIEKESLDGPIVKQLERGGRAVVKMDWREN
ITVPLQTDLRKFRTYKGGSVRDLLRAMRNKKHHYRELPAEVRETLGSLPD
DFVCYFTSRFPHLLAHTYRAMELCSHERLFQPYYFHE
3D structure
PDB6hx1 Binding to an Unusual Inactive Kinase Conformation by Highly Selective Inhibitors of Inositol-Requiring Enzyme 1 alpha Kinase-Endoribonuclease.
ChainA
Resolution2.14 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D688 K690 N693 D711 T734
Catalytic site (residue number reindexed from 1) D117 K119 N122 D140 T161
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
3.1.26.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GXK A L577 G578 K599 Y628 I642 C645 A646 F712 L714 H723 L16 G17 K38 Y57 I71 C74 A75 F141 L143 H150 MOAD: ic50=1.6uM
PDBbind-CN: -logKd/Ki=6.52,IC50=0.303uM
Gene Ontology
Molecular Function
GO:0004521 RNA endonuclease activity
GO:0004540 RNA nuclease activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006397 mRNA processing
GO:0006468 protein phosphorylation
GO:0030968 endoplasmic reticulum unfolded protein response

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Molecular Function
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Biological Process
External links
PDB RCSB:6hx1, PDBe:6hx1, PDBj:6hx1
PDBsum6hx1
PubMed30779566
UniProtO75460|ERN1_HUMAN Serine/threonine-protein kinase/endoribonuclease IRE1 (Gene Name=ERN1)

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