Structure of PDB 6hvj Chain A

Receptor sequence
>6hvjA (length=430) Species: 9606 (Homo sapiens) [Search protein sequence]
ELTQSRVQKIWVPVHNSPTVIVMVGLPARGKTYISKKLTRYLNWIGVPTK
VFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKE
GGQIAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIME
VKISSPDYKDCNSAEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVID
VGRRFLVNRVQDHIQSRIVYYLMNIHVQPRTIYLCRHGENEHNLQGRIGG
DSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQ
WKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTGESYQDLV
QRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTV
LKLTPVAYGCRVESIYLNVESVCTHRERSE
3D structure
PDB6hvj Discovery and Structure-Activity Relationships of N-Aryl 6-Aminoquinoxalines as Potent PFKFB3 Kinase Inhibitors.
ChainA
Resolution2.28 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) R252 H253 N259 S302 E322 H387
Catalytic site (residue number reindexed from 1) R236 H237 N243 S286 E306 H371
Enzyme Commision number 2.7.1.105: 6-phosphofructo-2-kinase.
3.1.3.46: fructose-2,6-bisphosphate 2-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GV8 A R45 Y49 I50 S152 C154 V159 N163 V167 V214 I241 A423 R29 Y33 I34 S136 C138 V143 N147 V151 V198 I225 A407 MOAD: ic50=0.028uM
PDBbind-CN: -logKd/Ki=7.55,IC50=0.028uM
BS02 F6P A G265 E322 Y333 R347 K351 Y362 Q388 R392 G249 E306 Y317 R331 K335 Y346 Q372 R376
BS03 PO4 A A44 R45 G46 K47 T48 K168 A28 R29 G30 K31 T32 K152
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003873 6-phosphofructo-2-kinase activity
GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006000 fructose metabolic process
GO:0006003 fructose 2,6-bisphosphate metabolic process
GO:0006096 glycolytic process
GO:0006915 apoptotic process
GO:0010001 glial cell differentiation
GO:0016310 phosphorylation
GO:0046835 carbohydrate phosphorylation
GO:0061744 motor behavior
Cellular Component
GO:0005654 nucleoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6hvj, PDBe:6hvj, PDBj:6hvj
PDBsum6hvj
PubMed30378281
UniProtQ16875|F263_HUMAN 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (Gene Name=PFKFB3)

[Back to BioLiP]