Structure of PDB 6hvf Chain A

Receptor sequence
>6hvfA (length=246) Species: 9031 (Gallus gallus) [Search protein sequence]
KDAWEIPRESLRLEVKLGQGGEVWMGTWNGTTRVAIKTFLQEAQVMKKLR
HEKLVQLYAVVSEEPIYIVMEYMSKGCLLDFLKGEMGKYLRLPQLVDMAA
QIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFPIKWTAPEAALYG
RFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPEC
PESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
3D structure
PDB6hvf Inhibition of osimertinib-resistant epidermal growth factor receptor EGFR-T790M/C797S.
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D386 R388 A390 N391 D404
Catalytic site (residue number reindexed from 1) D118 R120 A122 N123 D136
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GUT A V281 A293 M341 S342 G344 C345 L393 V23 A35 M73 S74 G76 C77 L125
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6hvf, PDBe:6hvf, PDBj:6hvf
PDBsum6hvf
PubMed31857889
UniProtP00523|SRC_CHICK Proto-oncogene tyrosine-protein kinase Src (Gene Name=SRC)

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