Structure of PDB 6hu2 Chain A

Receptor sequence
>6hu2A (length=401) Species: 6183 (Schistosoma mansoni) [Search protein sequence]
SVGIVYGDQYRQLCCSSPKFGDRYALVMDLINAYKLIPELSRVPPLQWDS
PSRMYEAVTAFHSTEYVDALKKLQMLHCEEKELTADDELLMDSFSLNYDC
PGFPSVFDYSLAAVQGSLAAASALICRHCEVVINWGGGWHHAKRSEASGF
CYLNDIVLAIHRLVSSTRQTRVLYVDLDLHHGDGVEEAFWYSPRVVTFSV
HHASPGFFPGTGTWNLPIFLNGAGRGRFSAFNLPLEEGINDLDWSNAIGP
ILDSLNIVIQPSYVVVQCGADCLATDPHRIFRLTNFYPSLSGYLYAIKKI
LSWKVPTLILGGGGYNFPDTARLWTRVTALTIEEVKGKKMTISPEIPEHS
YFSRYGPDFELDIDYFPDSIQKHHRRILEQLRNYADLNKLIYDYDQVYQL
Y
3D structure
PDB6hu2 Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants.
ChainA
Resolution1.986 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.98: histone deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D186 H188 D285 D178 H180 D271
BS02 T34 A K20 H142 G150 D186 H188 F216 H292 Y341 K19 H141 G149 D178 H180 F208 H278 Y315 MOAD: ic50=1260nM
PDBbind-CN: -logKd/Ki=5.90,IC50=1260nM
Gene Ontology
Molecular Function
GO:0004407 histone deacetylase activity
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0006338 chromatin remodeling
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6hu2, PDBe:6hu2, PDBj:6hu2
PDBsum6hu2
PubMed30347148
UniProtA5H660

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