Structure of PDB 6hso Chain A

Receptor sequence

>6hsoA (length=412) Species: 10116 (Rattus norvegicus) [Search protein sequence]

SPFPLTSMDKAFITVLEMTPVLGTEIINYRDGMGRVLAQDVYAKDNLPPF
PASVKDGYAVRAADGPGDRFIIGESQAGEQPTQTVMPGQVMRVTTGAPIP
CGADAVVQVEDTELIRESDDGTEELEVRILVQARPGQDIRPIGHDIKRGE
CVLAKGTHMGPSEIGLLATVGVTEVEVNKFPVVAVMSTGNELLNPEDDLL
PGKIRDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLNALNEGISRADVI
ITSGGVSMGEKDYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATLDIDGVR
KIIFALPGNPVSAVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLD
PRPEYHRCILTWHHQEPLPWAQSTGLMSMRSANGLLMLPPKTEQYVELHK
GEVVDVMVIGRL

3D structure

PDB

6hso Elucidating the Molecular Basis for Inhibitory Neurotransmission Regulation by Artemisinins.

Chain

Resolution

1.95 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.10.1.1: molybdopterin molybdotransferase.
2.7.7.75: molybdopterin adenylyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	A	M326 D327 F330 R653 I656 Y673 M711 P713 Y719 D729	M8 D9 F12 R335 I338 Y355 M387 P389 Y395 D405
BS02	peptide	A	R660 E684 K724	R342 E366 K400
BS03	ADP	A	E509 L510 D524 S525 N526 G572 G573 V574 S575 D580 G626 N627 P628	E191 L192 D206 S207 N208 G254 G255 V256 S257 D262 G308 N309 P310
BS04	3F7	A	H723 K724 E726	H399 K400 E402

Gene Ontology

	Biological Process
GO:0006777	Mo-molybdopterin cofactor biosynthetic process
GO:0032324	molybdopterin cofactor biosynthetic process

View graph for
Biological Process

External links

PDB	RCSB:6hso, PDBe:6hso, PDBj:6hso
PDBsum	6hso
PubMed	30704910
UniProt	Q03555\|GEPH_RAT Gephyrin (Gene Name=Gphn)

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