Structure of PDB 6hrz Chain A

Receptor sequence
>6hrzA (length=195) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
TQEERSAATREALITGARKLWGLRGYAEVGTPEIATEAGVTRGAMYHQFA
DKAALFRDVVEVVEQDVMARMATLVAASGAATPADAIRAAVDAWLEVSGD
PEVRQLILLDAPVVLGWAGFRDVAQRYSLGMTEQLITEAIRAGQLARQPV
RPLAQVLIGALDEAAMFIATADDPKRARRETRQVLRRLIDGMLNG
3D structure
PDB6hrz A fragment-based approach towards the discovery of N-substituted tropinones as inhibitors of Mycobacterium tuberculosis transcriptional regulator EthR2.
ChainA
Resolution1.57 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GO2 A W100 T138 I164 L167 D168 W94 T132 I158 L161 D162 PDBbind-CN: -logKd/Ki=4.00,IC50>100uM
BS02 GO2 A E70 V73 M74 M77 Y133 S134 M137 E64 V67 M68 M71 Y127 S128 M131 PDBbind-CN: -logKd/Ki=4.00,IC50>100uM
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005886 plasma membrane

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Cellular Component
External links
PDB RCSB:6hrz, PDBe:6hrz, PDBj:6hrz
PDBsum6hrz
PubMed30784877
UniProtO53623

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