Structure of PDB 6hry Chain A

Receptor sequence
>6hryA (length=191) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
RSAATREALITGARKLWGLRGYAEVGTPEIATEAGVTRGAMYHQFADKAA
LFRDVVEVVEQDVMARMATLVAASGAATPADAIRAAVDAWLEVSGDPEVR
QLILLDAPVVLGWAGFRDVAQRYSLGMTEQLITEAIRAGQLARQPVRPLA
QVLIGALDEAAMFIATADDPKRARRETRQVLRRLIDGMLNG
3D structure
PDB6hry A fragment-based approach towards the discovery of N-substituted tropinones as inhibitors of Mycobacterium tuberculosis transcriptional regulator EthR2.
ChainA
Resolution1.84 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GOE A E70 M74 W100 L114 A130 S134 D168 E60 M64 W90 L104 A120 S124 D158 PDBbind-CN: -logKd/Ki=4.00,IC50>100uM
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6hry, PDBe:6hry, PDBj:6hry
PDBsum6hry
PubMed30784877
UniProtO53623

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