Structure of PDB 6hr2 Chain A

Receptor sequence
>6hr2A (length=117) Species: 9606 (Homo sapiens) [Search protein sequence]
SPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELI
RKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSI
VLQSVFTSVRQKIEKED
3D structure
PDB6hr2 BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design.
ChainA
Resolution1.76 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FWZ A V1484 F1485 L1488 L1494 Y1497 V1505 A1536 F1539 N1540 I1546 V33 F34 L37 L43 Y46 V54 A85 F88 N89 I95 PDBbind-CN: -logKd/Ki=7.00,Ki=100nM
Gene Ontology
Biological Process
GO:0006338 chromatin remodeling
Cellular Component
GO:0016586 RSC-type complex

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Biological Process
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Cellular Component
External links
PDB RCSB:6hr2, PDBe:6hr2, PDBj:6hr2
PDBsum6hr2
PubMed31178587
UniProtP51532|SMCA4_HUMAN Transcription activator BRG1 (Gene Name=SMARCA4)

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