Structure of PDB 6hpu Chain A

Receptor sequence
>6hpuA (length=418) Species: 9606 (Homo sapiens) [Search protein sequence]
SRMQLSEEQAAVLRAVLKGQSIFFTGSAGTGKSYLLKRILGSLPPTGTVA
TASTGVAACHIGGTTLHAFAGIGSGQAPLAQCVALAQRPGVRQGWLNCQR
LVIDEISMVEADLFDKLEAVARAVRQQNKPFGGIQLIICGDFLQLPPVTK
GSQPPRFCFQSKSWKRCVPVTLELTKVWRQADQTFISLLQAVRLGRCSDE
VTRQLQATASHKVGRDGIVATRLCTHQDDVALTNERRLQELPGKVHRFEA
MDSNPELASTLDAQCPVSQLLQLKLGAQVMLVKNLSVSRGLVNGARGVVV
GFEAEGRGLPQVRFLCGVTEVIHADRWTVQATGGQLLSRQQLPLQLAWAM
SIHKSQGMTLDCVEISLGRVFASGQAYVALSRARSLQGLRVLDFDPMAVR
CDPRVLHFYATLRRGRSL
3D structure
PDB6hpu Structural and functional analysis of the nucleotide and DNA binding activities of the human PIF1 helicase.
ChainA
Resolution3.96 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A Q211 G231 G233 K234 S235 Y236 W380 R381 Q9 G29 G31 K32 S33 Y34 W178 R179
BS02 ALF A A230 K234 E307 Q346 R381 G559 M560 R584 A28 K32 E105 Q144 R179 G357 M358 R382
BS03 MG A S235 G559 S33 G357
Gene Ontology
Molecular Function
GO:0003678 DNA helicase activity
Biological Process
GO:0000723 telomere maintenance
GO:0006281 DNA repair

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6hpu, PDBe:6hpu, PDBj:6hpu
PDBsum6hpu
PubMed30698796
UniProtQ9H611|PIF1_HUMAN ATP-dependent DNA helicase PIF1 (Gene Name=PIF1)

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