Structure of PDB 6hn1 Chain A

Receptor sequence

>6hn1A (length=583) Species: 9925 (Capra hircus)

DTHKSEIAHRFNDLGEENFQGLVLIAFSQYLQQCPFDEHVKLVKELTEFA
KTCVADESHAGCDKSLHTLFGDELCKVATLRETYGDMADCCEKQEPERNE
CFLKHKDDSPDLPKLKPEPDTLCAEFKADEKKFWGKYLYEVARRHPYFYA
PELLYYANKYNGVFQECCQAEDKGACLLPKIETMREKVLASSARQRLRCA
SIQKFGERALKAWSVARLSQKFPKADFTDVTKIVTDLTKVHKECCHGDLL
ECADDRADLAKYICDHQDTLSSKLKECCDKPVLEKSHCIAEIDKDAVPEN
LPPLTADFAEDKEVCKNYQEAKDVFLGSFLYEYSRRHPEYAVSVLLRLAK
EYEATLEDCCAKEDPHACYATVFDKLKHLVDEPQNLIKKNCELFEKHGEY
GFQNALIVRYTRKAPQVSTPTLVEISRSLGKVGTKCCAKPESERMPCTED
YLSLILNRLCVLHEKTPVSEKVTKCCTESLVNRRPCFSDLTLDETYVPKP
FDGESFTFHADICTLPDTEKQIKKQTALVELLKHKPKATDEQLKTVMENF
VAFVDKCCAADDKEGCFLLEGPKLVASTQAALA

3D structure

• PDB: 6hn1 Structural Investigation of Diclofenac Binding to Ovine, Caprine, and Leporine Serum Albumins.
• Chain: A
• Resolution: 1.55 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	DIF	A	L386 I387 N390 F402 Y410 V432 T448 R484 S488	L386 I387 N390 F402 Y410 V432 T448 R484 S488
BS02	DIF	A	N404 L528 L543 K544 M547 E548	N404 L528 L543 K544 M547 E548
BS03	DIF	A	Q20 V40 K44 K131 K132	Q20 V40 K44 K131 K132
BS04	DIF	A	L115 Y137 Y160 M184 R185	L115 Y137 Y160 M184 R185
BS05	DIF	A	K211 V215 T231 T235 D323 V324	K211 V215 T231 T235 D323 V324
BS06	DIF	A	F501 F506 T507 V546 L574 V575	F501 F506 T507 V546 L574 V575

Gene Ontology

Molecular Function

• GO:0008289 lipid binding
• GO:0046872 metal ion binding

Cellular Component

• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0005737 cytoplasm
• GO:0072562 blood microparticle

External links

• PDB: RCSB:6hn1, PDBe:6hn1, PDBj:6hn1
• PDBsum: 6hn1
• PubMed: 36675044
• UniProt: A0A452F7K4