Structure of PDB 6hn0 Chain A

Receptor sequence

>6hn0A (length=583) Species: 9940 (Ovis aries)

DTHKSEIAHRFNDLGEENFQGLVLIAFSQYLQQCPFDEHVKLVKELTEFA
KTCVADESHAGCDKSLHTLFGDELCKVATLRETYGDMADCCEKQEPERNE
CFLNHKDDSPDLPKLKPEPDTLCAEFKADEKKFWGKYLYEVARRHPYFYA
PELLYYANKYNGVFQECCQAEDKGACLLPKIDAMREKVLASSARQRLRCA
SIQKFGERALKAWSVARLSQKFPKADFTDVTKIVTDLTKVHKECCHGDLL
ECADDRADLAKYICDHQDALSSKLKECCDKPVLEKSHCIAEVDKDAVPEN
LPPLTADFAEDKEVCKNYQEAKDVFLGSFLYEYSRRHPEYAVSVLLRLAK
EYEATLEDCCAKEDPHACYATVFDKLKHLVDEPQNLIKKNCELFEKHGEY
GFQNALIVRYTRKAPQVSTPTLVEISRSLGKVGTKCCAKPESERMPCTED
YLSLILNRLCVLHEKTPVSEKVTKCCTESLVNRRPCFSDLTLDETYVPKP
FDEKFFTFHADICTLPDTEKQIKKQTALVELLKHKPKATDEQLKTVMENF
VAFVDKCCAADDKEGCFVLEGPKLVASTQAALA

3D structure

• PDB: 6hn0 Structural Investigation of Diclofenac Binding to Ovine, Caprine, and Leporine Serum Albumins.
• Chain: A
• Resolution: 2.12 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	DIF	A	L386 I387 N390 F402 V432 G433 T448 L452 R484 S488	L386 I387 N390 F402 V432 G433 T448 L452 R484 S488
BS02	DIF	A	N404 L543 K544 M547	N404 L543 K544 M547
BS03	DIF	A	V40 K44 K131 K132 G135	V40 K44 K131 K132 G135
BS04	DIF	A	L115 P117 Y137 Y160 M184 R185 V188	L115 P117 Y137 Y160 M184 R185 V188
BS05	DIF	A	R208 K211 V215 T231 T235	R208 K211 V215 T231 T235
BS06	DIF	A	E186 L189 A190 A193 E424 R458	E186 L189 A190 A193 E424 R458

Gene Ontology

Molecular Function

• GO:0008289 lipid binding
• GO:0046872 metal ion binding
• GO:1903981 enterobactin binding

Cellular Component

• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0005737 cytoplasm
• GO:0072562 blood microparticle

External links

• PDB: RCSB:6hn0, PDBe:6hn0, PDBj:6hn0
• PDBsum: 6hn0
• PubMed: 36675044
• UniProt: P14639|ALBU_SHEEP Albumin (Gene Name=ALB)