Structure of PDB 6hmp Chain A

Receptor sequence
>6hmpA (length=286) Species: 9606 (Homo sapiens) [Search protein sequence]
RYRLGRKIGSGSFGDIYLGTDIAAEEVAIKLECVKTKHPQLHIESKIYKM
MQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLL
ADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRD
ARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNL
GSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSL
RFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLK
3D structure
PDB6hmp 2-Azo-, 2-diazocine-thiazols and 2-azo-imidazoles as photoswitchable kinase inhibitors: limitations and pitfalls of the photoswitchable inhibitor approach.
ChainA
Resolution2.039 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
2.7.11.26: [tau protein] kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GEW A S17 G18 I23 A36 K38 M80 M82 L85 K130 D132 L135 I148 S10 G11 I16 A28 K30 M72 M74 L77 K122 D124 L127 I140 MOAD: ic50=218nM
PDBbind-CN: -logKd/Ki=6.86,IC50=138nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6hmp, PDBe:6hmp, PDBj:6hmp
PDBsum6hmp
PubMed30924488
UniProtP48730|KC1D_HUMAN Casein kinase I isoform delta (Gene Name=CSNK1D)

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