Structure of PDB 6hle Chain A

Receptor sequence
>6hleA (length=473) Species: 9606 (Homo sapiens) [Search protein sequence]
VYQEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEK
NHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANN
GVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPED
DGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGY
TNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQ
KCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNA
NDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEP
KDIGKRLEVRKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSP
MGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEAN
NYGTLTKFTLVLYGTASGSLVPR
3D structure
PDB6hle Design, Synthesis, and Characterization of Macrocyclic Inhibitors of the Proprotein Convertase Furin.
ChainA
Resolution1.994 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.75: furin.
Interaction with ligand
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function

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Biological Process
External links
PDB RCSB:6hle, PDBe:6hle, PDBj:6hle
PDBsum6hle
PubMed30680958
UniProtP09958|FURIN_HUMAN Furin (Gene Name=FURIN)

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