Structure of PDB 6hlb Chain A

Receptor sequence

>6hlbA (length=467) Species: 9606 (Homo sapiens)

VYQEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEK
NHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANN
GVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPED
DGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGY
TNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQ
KCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNA
NDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEP
KDIGKRLEVRKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSP
MGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEAN
NYGTLTKFTLVLYGTAS

3D structure

• PDB: 6hlb Design, Synthesis, and Characterization of Macrocyclic Inhibitors of the Proprotein Convertase Furin.
• Chain: A
• Resolution: 2.0 Å

Enzymatic activity

• Enzyme Commision number: 3.4.21.75: furin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	D154 L227 V231 E236 W254 G255 E257 D264 Y308	D46 L119 V123 E128 W146 G147 E149 D156 Y200
BS02	CA	A	D174 D179 D181 S253 W254 G255 P256 D258 A292 D306	D66 D71 D73 S145 W146 G147 P148 D150 A184 D198
BS03	CA	A	D115 D162 V205 N208 V210 G212	D7 D54 V97 N100 V102 G104
BS04	CA	A	D258 D301 E331	D150 D193 E223

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0008236 serine-type peptidase activity

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:6hlb, PDBe:6hlb, PDBj:6hlb
• PDBsum: 6hlb
• PubMed: 30680958
• UniProt: P09958|FURIN_HUMAN Furin (Gene Name=FURIN)