Structure of PDB 6hkx Chain A

Receptor sequence
>6hkxA (length=320) Species: 9606 (Homo sapiens) [Search protein sequence]
KNIQVVVRCRPFNHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGA
STKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEE
YTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNP
SSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTA
ATLMNAYSSRSHSVFSVTIHMKETTLVKIGKLNLVDLAGSENNINQSLLT
LGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLE
ETLSTLEYAHRAKNILNKPE
3D structure
PDB6hkx Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5-Inhibitor Complexes.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A R26 P27 G108 G110 K111 T112 F113 E118 R10 P11 G84 G86 K87 T88 F89 E94
BS02 GCE A E116 G117 E118 R119 A133 I136 P137 Y211 L214 E215 G217 A218 R221 E92 G93 E94 R95 A109 I112 P113 Y187 L190 E191 G193 A194 R197 PDBbind-CN: -logKd/Ki=9.34,Kd=456.3pM
BindingDB: IC50=6.0nM
Gene Ontology
Molecular Function
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0008017 microtubule binding
Biological Process
GO:0007018 microtubule-based movement

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Molecular Function
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Biological Process
External links
PDB RCSB:6hkx, PDBe:6hkx, PDBj:6hkx
PDBsum6hkx
PubMed31488701
UniProtP52732|KIF11_HUMAN Kinesin-like protein KIF11 (Gene Name=KIF11)

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