Structure of PDB 6hkn Chain A

Receptor sequence
>6hknA (length=333) Species: 9606 (Homo sapiens) [Search protein sequence]
EYEIIETIAYGVVSSARRQQVAIKKIPNAFDVVTNAKRTLRELKILKHFK
HDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVR
YFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTS
PAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQ
LFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWE
TVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCA
PPFDFAFDREALTRERIKEAIVAEIEDFHARRE
3D structure
PDB6hkn Discovery and Characterization of the Potent and Highly Selective (Piperidin-4-yl)pyrido[3,2- d]pyrimidine Based in Vitro Probe BAY-885 for the Kinase ERK5.
ChainA
Resolution2.33 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D182 K184 S186 N187 D200 T224
Catalytic site (residue number reindexed from 1) D122 K124 S126 N127 D140 T164
Enzyme Commision number 2.7.11.24: mitogen-activated protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 G9E A I61 Y66 A82 K84 I86 E102 L103 L106 L137 D138 M140 L189 D200 I8 Y10 A22 K24 I26 E42 L43 L46 L77 D78 M80 L129 D140 MOAD: ic50=0.051uM
PDBbind-CN: -logKd/Ki=7.29,IC50=0.051uM
BindingDB: IC50=51nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6hkn, PDBe:6hkn, PDBj:6hkn
PDBsum6hkn
PubMed30563338
UniProtQ13164|MK07_HUMAN Mitogen-activated protein kinase 7 (Gene Name=MAPK7)

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