Structure of PDB 6hkm Chain A

Receptor sequence
>6hkmA (length=327) Species: 9606 (Homo sapiens) [Search protein sequence]
EYEIIETIGNVVSSAQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDN
IIAIKDILRPVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLY
QLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSEHQY
FMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKN
YVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPQPVPWETVYPGADR
QALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPPFDFAFD
REALTRERIKEAIVAEIEDFHARREGI
3D structure
PDB6hkm Discovery and Characterization of the Potent and Highly Selective (Piperidin-4-yl)pyrido[3,2- d]pyrimidine Based in Vitro Probe BAY-885 for the Kinase ERK5.
ChainA
Resolution2.47 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D182 K184 S186 N187 D200 T224
Catalytic site (residue number reindexed from 1) D118 K120 S122 N123 D136 T158
Enzyme Commision number 2.7.11.24: mitogen-activated protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 G92 A I61 A82 K84 I86 E102 L103 L106 V135 L137 M140 D200 I8 A19 K21 I23 E39 L40 L43 V71 L73 M76 D136 MOAD: ic50=270nM
PDBbind-CN: -logKd/Ki=6.57,IC50=0.27uM
BindingDB: IC50=270nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6hkm, PDBe:6hkm, PDBj:6hkm
PDBsum6hkm
PubMed30563338
UniProtQ13164|MK07_HUMAN Mitogen-activated protein kinase 7 (Gene Name=MAPK7)

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