Structure of PDB 6hie Chain A

Receptor sequence
>6hieA (length=130) Species: 9606 (Homo sapiens) [Search protein sequence]
SMQEEDTFRELRIFLRNVTHRLAIDKRFRVFTKPVDPDEVPDYVTVIKQP
MDLSSVISKIDLHKYLTVKDYLRDIDLICSNALEYNPDRDPGDRLIRHRA
CALRDTAYAIIKEELDEDFEQLCEEIQESR
3D structure
PDB6hie Hitting a Moving Target: Simulation and Crystallography Study of ATAD2 Bromodomain Blockers.
ChainA
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 G7Q A Y1063 N1064 D1068 G1070 D1071 I1074 Y85 N86 D90 G92 D93 I96 BindingDB: Kd=25000nM,IC50=15000nM
External links
PDB RCSB:6hie, PDBe:6hie, PDBj:6hie
PDBsum6hie
PubMed32832026
UniProtQ6PL18|ATAD2_HUMAN ATPase family AAA domain-containing protein 2 (Gene Name=ATAD2)

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