Structure of PDB 6hi0 Chain A

Receptor sequence
>6hi0A (length=428) Species: 573 (Klebsiella pneumoniae) [Search protein sequence]
MLDPNLLRTEPDAVAEKLARRGFKLDVDKLRALEERRKVLQVQTENLQAE
RNSRSKSIGQAKARDIEPLRLEVNKLGEQLDAAKSELETLLAEIRDIALA
IPNIPHDDVPVGRDENDNVEVSRWGTPRQFDFEVRDHVTLGEMHGGLDFA
AAVKLTGSRFVVMKGQLARLHRALAQFMLDLHTEQHGYSENYVPYLVNQD
TLYGTGQLPKFAGDLFHTRPLEEEADSSNYALIPTAEVPLTNLVRDEIID
EDDLPIKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQIVRPEDSM
AALEEMTGHAEKVLQLLGLPYRKVALCTGDMGFSACKTYDLEVWVPAQNT
YREISSCSNVWDFQARRMQARCRSKSDKKTRLVHTLNGSGLAVGRTLVAL
MENYQQADGRIEIPEVLRPYMRGLEYIG
3D structure
PDB6hi0 Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases.
ChainA
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.11: serine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FZK A T237 E239 R268 F287 K289 E291 E355 I356 S357 S358 N389 S391 A394 R397 T235 E237 R266 F285 K287 E289 E353 I354 S355 S356 N387 S389 A392 R395
BS02 CA A E239 N389 E237 N387
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004828 serine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006434 seryl-tRNA aminoacylation
GO:0016260 selenocysteine biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6hi0, PDBe:6hi0, PDBj:6hi0
PDBsum6hi0
PubMed31869198
UniProtA6T6Z0|SYS_KLEP7 Serine--tRNA ligase (Gene Name=serS)

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