Structure of PDB 6hh6 Chain A

Receptor sequence
>6hh6A (length=506) Species: 9606 (Homo sapiens) [Search protein sequence]
DKKWLGTPIEEMRRMPRCGIRLPLLRPSANHTVTIRVDLLRAGEVPKPFP
THYKDLWDNKHVKMPCSEQNLYPVAGSRWELIQTALLNKFTRPQNLKDAI
LKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNI
CTQPIPLLAAAMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYP
DINFNRLFEGRSSRKPEKLKTLFCYFRRVTAAAPTGLVTFTRQSLEDFPE
WERCEKPLTRLHVTYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEI
RFLINPELIISRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWSRSHED
GSERDDWQRRCTEIVAIDALHFRRYLDQFVPEKMRRELNKAYCGFLRPGV
SSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSEL
MRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIY
HAVESC
3D structure
PDB6hh6 (ADP-ribosyl)hydrolases: Structural Basis for Differential Substrate Recognition and Inhibition.
ChainA
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.143: poly(ADP-ribose) glycohydrolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A3R A I726 E727 F738 N740 V753 Q754 E755 E756 Y795 N869 G871 G873 A874 F875 F902 I269 E270 F281 N283 V296 Q297 E298 E299 Y338 N412 G414 G416 A417 F418 F445
Gene Ontology
Molecular Function
GO:0004649 poly(ADP-ribose) glycohydrolase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006282 regulation of DNA repair

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6hh6, PDBe:6hh6, PDBj:6hh6
PDBsum6hh6
PubMed30472116
UniProtQ86W56|PARG_HUMAN Poly(ADP-ribose) glycohydrolase (Gene Name=PARG)

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