Structure of PDB 6hh4 Chain A

Receptor sequence
>6hh4A (length=326) Species: 7897 (Latimeria chalumnae) [Search protein sequence]
VSLAQVRGALCGALLGDCMGAEFEGSDAVELPDVLEFVRLLEKEKKAGTL
FYTDDTAMTRAVIQSLIAKPDFDEVDMAKRFAEEYKKEPTRGYGAGVVQV
FKKLLSPKYSDVFQPAREQFDGKGSYGNGGAMRVASIALAYPNIQDVIKF
ARRSAQLTHASPLGYNGAILQALAVHFALQGELKRDTFLEQLIGEMERIE
GLPFCSRLKKIKEFLASSNVPKADIVDELGHGIAALESVPTAIYSFLHCM
ESDPDIPDLYNNLQRTIIYSISLGGDTDTIATMAGAIAGAYYGMDQVTPS
WKRSCEAIVETEESAVKLYELYCKQL
3D structure
PDB6hh4 (ADP-ribosyl)hydrolases: Structural Basis for Differential Substrate Recognition and Inhibition.
ChainA
Resolution1.66 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.143: poly(ADP-ribose) glycohydrolase.
3.2.2.-
3.5.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A T62 D63 D64 D305 T53 D54 D55 D278
BS02 MG A E33 D303 D305 T306 E24 D276 D278 T279
BS03 F2R A E33 D63 D64 G101 G103 G105 V106 F129 S134 Y135 G136 N137 G138 H168 I260 D303 D305 T306 E24 D54 D55 G92 G94 G96 V97 F120 S125 Y126 G127 N128 G129 H159 I233 D276 D278 T279
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004649 poly(ADP-ribose) glycohydrolase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006281 DNA repair
GO:0060546 negative regulation of necroptotic process
GO:0140290 peptidyl-serine ADP-deribosylation
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix

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Molecular Function
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Cellular Component
External links
PDB RCSB:6hh4, PDBe:6hh4, PDBj:6hh4
PDBsum6hh4
PubMed30472116
UniProtH3BCW1|ADPRS_LATCH ADP-ribosylhydrolase ARH3 (Gene Name=adprs)

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