Structure of PDB 6hh1 Chain A

Receptor sequence
>6hh1A (length=303) Species: 9606 (Homo sapiens) [Search protein sequence]
GNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKS
DAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGG
PTLVITEYCCYGDLLNFLRRKRDSFICSKTSPAIELALDLEDLLSFSYQV
AKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVK
GNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVD
SKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEK
QIS
3D structure
PDB6hh1 Structure of c-Kit with allosteric inhibitor 3G8
ChainA
Resolution2.25 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D810
Catalytic site (residue number reindexed from 1) D184
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 G4E A L595 A621 K623 L644 C673 L799 I808 C809 D810 F811 L31 A57 K59 L80 C109 L173 I182 C183 D184 F185
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:6hh1, PDBe:6hh1, PDBj:6hh1
PDBsum6hh1
PubMed
UniProtP10721|KIT_HUMAN Mast/stem cell growth factor receptor Kit (Gene Name=KIT)

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