Structure of PDB 6hg5 Chain A

Receptor sequence

>6hg5A (length=389) Species: 383550 (Influenza A virus (A/duck/England/1/1956(H11N6)))

RTFLNLTKPLCEVNSWHILSKDNAIRIGEDAHILVTREPYLSCDPQGCRM
FALSQGTTLRGRHANGTIHDRSPFRALISWEMGQAPSPYNTRVECIGWSS
TSCHDGMSRMSICMSGPNNNASAVVWYGGRPITEIPSWAGNILRTQESEC
VCHKGVCPVVMTDGPANNRAATKIIYFKEGKIQKIEELAGNAQHIEECSC
YGAGGVIKCICRDNWKGANRPVITIDPEMMTHTSKYLCSKVLTDTSRPND
PTNGNCDAPITGGSPDPGVKGFAFLDGENSWLGRTISKDSRSGYEMLKVP
NAETDIQSGPISNQVIVNNQNWSGYSGAFIDYWANKECFNPCFYVELIRG
RPKESSVLWTSNSIVALCGSKKRLGSWSWHDGAEIIYFE

3D structure

• PDB: 6hg5 High Resolution Structures of Viral Neuraminidase with Drugs Bound in the Active Site.
• Chain: A
• Resolution: 1.6 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D151 E278 R293 R372 Y406
• Catalytic site (residue number reindexed from 1): D70 E197 R212 R291 Y325
• Enzyme Commision number: 3.2.1.18: exo-alpha-sialidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	BMA	A	I392 S393	I311 S312
BS02	MAN	A	P391 N394	P310 N313
BS03	MAN	A	E376 N394	E295 N313
BS04	MAN	A	D331 R365	D250 R284
BS05	G39	A	R118 E119 D151 R152 R225 E277 R293 N295 R372 Y406	R37 E38 D70 R71 R144 E196 R212 N214 R291 Y325
BS06	CA	A	D294 G298 D325 P348	D213 G217 D244 P267

Gene Ontology

Molecular Function

• GO:0004308 exo-alpha-sialidase activity

Biological Process

• GO:0005975 carbohydrate metabolic process

Cellular Component

• GO:0016020 membrane
• GO:0033644 host cell membrane
• GO:0055036 virion membrane

External links

• PDB: RCSB:6hg5, PDBe:6hg5, PDBj:6hg5
• PDBsum: 6hg5
• UniProt: Q6XV27|NRAM_I56A2 Neuraminidase (Gene Name=NA)