Structure of PDB 6hey Chain A

Receptor sequence
>6heyA (length=277) Species: 9606 (Homo sapiens) [Search protein sequence]
AVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSEVPVAIKTLKAGYT
EKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKF
LREKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVC
KVSDFGLSKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYW
ELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVS
ILDKLIRAPDSLKTLADFDPRVSIRLP
3D structure
PDB6hey Effects of NVP-BHG712 chemical modifications on EPHA2 binding and affinity
ChainA
Resolution1.367 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D739 A741 R743 N744 D757 P780
Catalytic site (residue number reindexed from 1) D136 A138 R140 N141 D154 P161
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FZW A V627 A644 K646 E663 M667 I676 T692 Y694 M695 Y735 L746 S756 D757 F758 V28 A41 K43 E60 M64 I73 T89 Y91 M92 Y132 L143 S153 D154 F155
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6hey, PDBe:6hey, PDBj:6hey
PDBsum6hey
PubMed
UniProtP29317|EPHA2_HUMAN Ephrin type-A receptor 2 (Gene Name=EPHA2)

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