Structure of PDB 6he2 Chain A

Receptor sequence

>6he2A (length=460) Species: 391953 (Aquincola tertiaricarbonis) [Search protein sequence]

HHHSGMEEWNFPVEYDENYLPPADSRYWFPRRETMPAAERDKAILGRLQQ
VCQYAWEHAPFYRRKWEEAGFQPSQLKSLEDFEARVPVVKKTDLRESQAA
HPPFGDYVCVPNSEIFHVHGTSRPTAFGIGRADWRAIANAHARIMWGMGI
RPGDLVCVAAVFSLYMGSWGALAGAERLRAKAFPFGAGAPGMSARLVQWL
DTMKPAAFYGTPSYAIHLAEVAREEKLNPRNFGLKCLFFSGEPGASVPGV
KDRIEEAYGAKVYDCGSMAEMSPFMNVAGTEQSNDGMLCWQDIIYTEVCD
PANMRRVPYGQRGTPVYTHLERTSQPMIRLLSGDLTLWTNDENPCGRTYP
RLPQGIFGRIDDMFTIRGENIYPSEIDAALNQMSGYGGEHRIVITRMDEL
LLRVEPSESVHAAGAAALETFRTEASHRVQTVLGVRAKVELVAPNSIART
DFKARRVIDD

3D structure

PDB

6he2 Structures of 2-Hydroxyisobutyric Acid-CoA Ligase Reveal Determinants of Substrate Specificity and Describe a Multi-Conformational Catalytic Cycle.

Chain

Resolution

2.3 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

6.2.1.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	AMP	A	K86 G240 E241 P242 C264 S266 M267 A268 E269 D333 I355	K91 G241 E242 P243 C265 S267 M268 A269 E270 D334 I356
BS02	8LE	A	S239 G240 E241 P242 S266 A268 F273 D333 I355	S240 G241 E242 P243 S267 A269 F274 D334 I356
BS03	COA	A	G187 G190 S192 S212 Y213 H216	G188 G191 S193 S213 Y214 H217

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0016874	ligase activity

View graph for
Molecular Function

External links

PDB	RCSB:6he2, PDBe:6he2, PDBj:6he2
PDBsum	6he2
PubMed	31145912
UniProt	I3VE75

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