Structure of PDB 6hdy Chain A

Receptor sequence
>6hdyA (length=474) Species: 391953 (Aquincola tertiaricarbonis) [Search protein sequence]
SGMEEWNFPVEYDENYLPPADSRYWFPRRETMPAAERDKAILGRLQQVCQ
YAWEHAPFYRRKWEEAGFQPSQLKSLEDFEARVPVVKKTDLRESQAAHPP
FGDYVCVPNSEIFHVHGTSRPTAFGIGRADWRAIANAHARIMWGMGIRPG
DLVCVAAVFSLYMGSWGALAGAERLRAKAFPFGAGAPGMSARLVQWLDTM
KPAAFYGTPSYAIHLAEVAREEKLNPRNFGLKCLFFSGEPGASVPGVKDR
IEEAYGAKVYDCGSMAEMSPFMNVAGTEQSNDGMLCWQDIIYTEVCDPAN
MRRVPYGQRGTPVYTHLERTSQPMIRLLSGDLTLWTNDENPCGRTYPRLP
QGIFGRIDDMFTIRGENIYPSEIDAALNQMSGYGGEHRIVITRESAMDEL
LLRVEPSESVHAAGAAALETFRTEASHRVQTVLGVRAKVELVAPNSIART
DFKARRVIDDREVFRALNQQLQSS
3D structure
PDB6hdy Structures of 2-Hydroxyisobutyric Acid-CoA Ligase Reveal Determinants of Substrate Specificity and Describe a Multi-Conformational Catalytic Cycle.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.2.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3HL A Y164 S239 G265 S266 M267 A268 F273 Y162 S237 G263 S264 M265 A266 F271
BS02 8LQ A Y164 G166 S239 G240 E241 P242 C264 G265 S266 A268 F273 D333 I355 R358 K455 Y162 G164 S237 G238 E239 P240 C262 G263 S264 A266 F271 D331 I353 R356 K453
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016874 ligase activity

View graph for
Molecular Function
External links
PDB RCSB:6hdy, PDBe:6hdy, PDBj:6hdy
PDBsum6hdy
PubMed31145912
UniProtI3VE75

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