Structure of PDB 6hdq Chain A

Receptor sequence
>6hdqA (length=123) Species: 9606 (Homo sapiens) [Search protein sequence]
NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLN
LPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPG
DDIVLMAEALEKLFLQKINELPT
3D structure
PDB6hdq Aiming to Miss a Moving Target: Bromo and Extra Terminal Domain (BET) Selectivity in Constrained ATAD2 Inhibitors.
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FZE A W81 P82 L92 W38 P39 L49 MOAD: ic50=5.01uM
PDBbind-CN: -logKd/Ki=7.00,IC50=0.1uM
BindingDB: IC50=5012nM
External links
PDB RCSB:6hdq, PDBe:6hdq, PDBj:6hdq
PDBsum6hdq
PubMed30226378
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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