Structure of PDB 6hdo Chain A

Receptor sequence
>6hdoA (length=130) Species: 9606 (Homo sapiens) [Search protein sequence]
SMQEEDTFRELRIFLRNVTHRLAIDKRFRVFTKPVDPDEVPDYVTVIKQP
MDLSSVISKIDLHKYLTVKDYLRDIDLICSNALEYNPDRDPGDRLIRHRA
CALRDTAYAIIKEELDEDFEQLCEEIQESR
3D structure
PDB6hdo Aiming to Miss a Moving Target: Bromo and Extra Terminal Domain (BET) Selectivity in Constrained ATAD2 Inhibitors.
ChainA
Resolution2.61 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FZH A V1008 V1013 D1014 E1017 V1018 Y1063 N1064 G1070 D1071 I1074 R1077 V30 V35 D36 E39 V40 Y85 N86 G92 D93 I96 R99 PDBbind-CN: -logKd/Ki=6.60,IC50=0.25uM
BindingDB: IC50=251nM
External links
PDB RCSB:6hdo, PDBe:6hdo, PDBj:6hdo
PDBsum6hdo
PubMed30226378
UniProtQ6PL18|ATAD2_HUMAN ATPase family AAA domain-containing protein 2 (Gene Name=ATAD2)

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