Structure of PDB 6hdn Chain A

Receptor sequence
>6hdnA (length=130) Species: 9606 (Homo sapiens) [Search protein sequence]
SMQEEDTFRELRIFLRNVTHRLAIDKRFRVFTKPVDPDEVPDYVTVIKQP
MDLSSVISKIDLHKYLTVKDYLRDIDLICSNALEYNPDRDPGDRLIRHRA
CALRDTAYAIIKEELDEDFEQLCEEIQESR
3D structure
PDB6hdn Aiming to Miss a Moving Target: Bromo and Extra Terminal Domain (BET) Selectivity in Constrained ATAD2 Inhibitors.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FZB A V1008 N1064 D1071 I1074 V30 N86 D93 I96 MOAD: ic50=3.16uM
PDBbind-CN: -logKd/Ki=4.30,IC50=50.12uM
BindingDB: IC50=25119nM
External links
PDB RCSB:6hdn, PDBe:6hdn, PDBj:6hdn
PDBsum6hdn
PubMed30226378
UniProtQ6PL18|ATAD2_HUMAN ATPase family AAA domain-containing protein 2 (Gene Name=ATAD2)

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