Structure of PDB 6hcw Chain A

Receptor sequence
>6hcwA (length=501) Species: 353152 (Cryptosporidium parvum Iowa II) [Search protein sequence]
SHYTDNRYKMMECIKDAGRPFYPHKFKISMSLPAYALKYGNVENGYIDKD
TTLSLSGRVTSIRSSSSKLIFYDIFCEEQKVQIIANIMEHDISTGEFSVS
HSEIRRGDVVGFTGFPGKSKRGELSLFSKSVVLLSPCYHMLPTAISGLKD
QEVRYRQRYLDLMLNEESRKVFKLRSRAIKYIRNYFDRLGFLEVETPMLN
MIYGGAAARPFITYHNELETQLYMRIAPELYLKQLIVGGLDKVYEIGKNF
RNEGIDLTHNPEFTAMEFYMAYADYYDLMDLTEELISGLVLEIHGSLKIP
YHPDGPEGKCIEIDFTTPWKRFSFVEEIESGLGEKLKRPLDSQENIDFMV
EMCEKHEIELPHPRTAAKLLDKLAGHFVETKCTNPSFIIDHPQTMSPLAK
WHREKPEMTERFELFVLGKELCNAYTELNEPLQQRKFFEQQADAKASGDV
EACPIDETFCLALEHGLPPTGGWGLGIDRLIMFLADKNNIKEVILFPAMR
N
3D structure
PDB6hcw Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.
ChainA
Resolution1.46 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R295 E297 T302 H303 E464 N467 R523
Catalytic site (residue number reindexed from 1) R251 E253 T258 H259 E420 N423 R479
Enzyme Commision number 6.1.1.6: lysine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LYS A G249 E273 E311 Y313 N467 Y469 E471 G516 G205 E229 E267 Y269 N423 Y425 E427 G472
BS02 FYB A R295 E297 H303 N304 F307 E464 L465 G518 L519 G520 R523 R251 E253 H259 N260 F263 E420 L421 G474 L475 G476 R479 MOAD: ic50=0.13uM
PDBbind-CN: -logKd/Ki=6.89,IC50=0.13uM
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004824 lysine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006430 lysyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6hcw, PDBe:6hcw, PDBj:6hcw
PDBsum6hcw
PubMed30894487
UniProtQ5CR27

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