Structure of PDB 6hcp Chain A

Receptor sequence

>6hcpA (length=671) Species: 470 (Acinetobacter baumannii)

DTYAGGQVATSSNVGFLGSKKFLDTPFNTISYTDKYIEDKQAKDITEVIA
ATDPSIYTNGASGGWSENYYIRGYASSTNDMSMNGLFGITPFYRTSPEMF
GRVEVLKGPSALLNGMPPAGSVGGTVNLVTKYAADEPFARLTTTYMSDAQ
FGGHVDVGRRFGENKEFGVRINGMYRDGDAAVNDQSKESRLFSLGLDWQG
ENARVFVDAYDALDHVDGVTRGVNVSTAVGIPKPPKADTLLSPDWGSVET
KDKGAMIRGEYDFSDQLMAYAAYGQSTTEYKYNGASAGTITSSTGTLSST
LGQLAFDVDKKSADAGFKGKFETGSVKHQWVANATYYNHTQDDYGYRIIP
GFSDPVITNIYDPNPNWGPKPEFTPPFLFHSTLSTSSFGLADTLSFAQDK
VQLTLGLRHQTVKATSSVNTLPENAKSATTPGVALLIKATDKISVYANYI
EGLTKGDQAPATASNPGEIFPPQKTKQQELGLKVDLGTFAHTLSAFEITK
PSSYLDPSKLVNNLPTFVSDGEQRNRGIEWSFFGSPIEHVRLMGGFTYLD
PELTKTKSGGNDGHTAVAVPKNQAKLGAEWDTQVAQGTLTLSGNINAVSK
QYINAENTLSVPGRTLLDVGARYSTKVEDHPVTFRANIYNLTNKAYWAQP
QLTNLALGAPRTYMLSVSYDF

3D structure

• PDB: 6hcp Preacinetobactin not acinetobactin is essential for iron uptake by the BauA transporter of the pathogenAcinetobacter baumannii.
• Chain: A
• Resolution: 1.83 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	C8E	A	F578 T579 N604 S631	F546 T547 N572 S599
BS02	C8E	A	Q510 I560 Y580	Q478 I528 Y548
BS03	C8E	A	A610 G625	A578 G593
BS04	C8E	A	R693 Y695 L697	R661 Y663 L665

Gene Ontology

Molecular Function

• GO:0015343 siderophore-iron transmembrane transporter activity
• GO:0015344 siderophore uptake transmembrane transporter activity
• GO:0038023 signaling receptor activity

Biological Process

• GO:0006826 iron ion transport
• GO:0015891 siderophore transport
• GO:0033214 siderophore-dependent iron import into cell
• GO:0044718 siderophore transmembrane transport

Cellular Component

• GO:0009279 cell outer membrane

External links

• PDB: RCSB:6hcp, PDBe:6hcp, PDBj:6hcp
• PDBsum: 6hcp
• PubMed: 30558715
• UniProt: Q76HJ9