Structure of PDB 6hch Chain A

Receptor sequence
>6hchA (length=263) Species: 10116 (Rattus norvegicus) [Search protein sequence]
GANKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFK
YKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITYVREEVI
DFSKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRS
KIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYI
EQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLSEQGLLDKL
KNKWWYDKGECGS
3D structure
PDB6hch Crystal Structures of Potent Dimeric Positive Allosteric Modulators at the Ligand-Binding Domain of the GluA2 Receptor.
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLU A Y61 L90 T91 R96 G141 S142 T143 E193 Y61 L90 T91 R96 G141 S142 T143 E193
BS02 D45 A P105 S108 S217 K218 G219 S242 P105 S108 S217 K218 G219 S242
BS03 ZN A E42 H46 E42 H46
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:6hch, PDBe:6hch, PDBj:6hch
PDBsum6hch
PubMed30891120
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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