Structure of PDB 6hay Chain A

Receptor sequence
>6hayA (length=120) Species: 9606 (Homo sapiens) [Search protein sequence]
EKLSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYE
LIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYED
SIVLQSVFKSARQKIAKEEE
3D structure
PDB6hay BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design.
ChainA
Resolution2.24 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FX8 A V1408 F1409 L1412 L1418 Y1421 V1429 D1430 A1460 F1463 N1464 I1470 V35 F36 L39 L45 Y48 V56 D57 A87 F90 N91 I97 PDBbind-CN: -logKd/Ki=7.01,Kd=98nM
Gene Ontology
Biological Process
GO:0006338 chromatin remodeling
Cellular Component
GO:0016586 RSC-type complex

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Biological Process
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Cellular Component
External links
PDB RCSB:6hay, PDBe:6hay, PDBj:6hay
PDBsum6hay
PubMed31178587
UniProtP51531|SMCA2_HUMAN Probable global transcription activator SNF2L2 (Gene Name=SMARCA2)

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