Structure of PDB 6hax Chain A

Receptor sequence
>6haxA (length=115) Species: 9606 (Homo sapiens) [Search protein sequence]
LSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELI
RKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSI
VLQSVFKSARQKIAK
3D structure
PDB6hax BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design.
ChainA
Resolution2.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FWZ A V1408 F1409 L1412 L1418 Y1421 A1460 F1463 N1464 I1470 V33 F34 L37 L43 Y46 A85 F88 N89 I95 PDBbind-CN: -logKd/Ki=7.59,Ki=26nM
Gene Ontology
Biological Process
GO:0006338 chromatin remodeling
Cellular Component
GO:0016586 RSC-type complex

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Biological Process
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Cellular Component
External links
PDB RCSB:6hax, PDBe:6hax, PDBj:6hax
PDBsum6hax
PubMed31178587
UniProtP51531|SMCA2_HUMAN Probable global transcription activator SNF2L2 (Gene Name=SMARCA2)

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