Structure of PDB 6h9x Chain A

Receptor sequence
>6h9xA (length=428) Species: 573 (Klebsiella pneumoniae) [Search protein sequence]
MLDPNLLRTEPDAVAEKLARRGFKLDVDKLRALEERRKVLQVQTENLQAE
RNSRSKSIGQAKARDIEPLRLEVNKLGEQLDAAKSELETLLAEIRDIALA
IPNIPHDDVPVGRDENDNVEVSRWGTPRQFDFEVRDHVTLGEMHGGLDFA
AAVKLTGSRFVVMKGQLARLHRALAQFMLDLHTEQHGYSENYVPYLVNQD
TLYGTGQLPKFAGDLFHTRPLEEEADSSNYALIPTAEVPLTNLVRDEIID
EDDLPIKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQIVRPEDSM
AALEEMTGHAEKVLQLLGLPYRKVALCTGDMGFSACKTYDLEVWVPAQNT
YREISSCSNVWDFQARRMQARCRSKSDKKTRLVHTLNGSGLAVGRTLVAL
MENYQQADGRIEIPEVLRPYMRGLEYIG
3D structure
PDB6h9x Acylated sulfonamide adenosines as potent inhibitors of the adenylate-forming enzyme superfamily.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.11: serine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SSA A T237 E239 R268 E270 I282 R283 M284 F287 K289 E291 E355 I356 S357 S358 N389 S391 A394 R397 T235 E237 R266 E268 I280 R281 M282 F285 K287 E289 E353 I354 S355 S356 N387 S389 A392 R395 PDBbind-CN: -logKd/Ki=9.74,Ki=0.18nM
BS02 CA A E239 N389 E237 N387
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004828 serine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006434 seryl-tRNA aminoacylation
GO:0016260 selenocysteine biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6h9x, PDBe:6h9x, PDBj:6h9x
PDBsum6h9x
PubMed31048140
UniProtW9BNU9

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