Structure of PDB 6h8s Chain A

Receptor sequence
>6h8sA (length=291) Species: 10090 (Mus musculus) [Search protein sequence]
SAHEYLLSASRVLRAEELHEKALDPFLLQAEFFEIPMNFVDPKEYDIPGL
VRKNRYKTILPNPHSRVRLTSPDPEDPLSSYINANYIRGYSGEEKVYIAT
QGPIVSTVADFWRMVWQERTPIIVMITNIEEMNEKCTEYWPEEQVVHDGV
EITVQKVIHTEDYRLRLISLRRGTEERTLKHYWFTSWPDQKTPDRAPPLL
HLVREVEEAAQQEGPHCSPIIVHCSAGIGRTGCFIATSICCQQLRREGVV
DILKTTCQLRQDRGGMIQTCEQYQFVHHAMSLYEKQLSHQS
3D structure
PDB6h8s Allosteric Activation of Striatal-Enriched Protein Tyrosine Phosphatase (STEP, PTPN5) by a Fragment-like Molecule.
ChainA
Resolution1.771 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FSZ A E341 V344 Y345 E455 A458 C465 I468 E93 V96 Y97 E207 A210 C217 I220 PDBbind-CN: -logKd/Ki=4.42,Kd=37.7uM
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6h8s, PDBe:6h8s, PDBj:6h8s
PDBsum6h8s
PubMed30207464
UniProtP54830|PTN5_MOUSE Tyrosine-protein phosphatase non-receptor type 5 (Gene Name=Ptpn5)

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