Structure of PDB 6h8c Chain A

Receptor sequence
>6h8cA (length=116) Species: 9606 (Homo sapiens) [Search protein sequence]
MGWMFKEDHSLEHRCVESAKIRAKYPDRVPVIVEKVSGSQIVDIDKRKYL
VPSDITVAQFMWIIRKRIQLPSEKAIFLFVDKTVPQSSLTMGQLYEKEKD
EDGFLYVAYSGENTFG
3D structure
PDB6h8c An atypical LIR motif within UBA5 (ubiquitin like modifier activating enzyme 5) interacts with GABARAP proteins and mediates membrane localization of UBA5.
ChainA
ResolutionN/A
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A M4 F5 E12 E17 Y25 R28 K46 R47 K48 Y49 L50 V51 P52 Q59 I63 K66 M4 F5 E12 E17 Y25 R28 K46 R47 K48 Y49 L50 V51 P52 Q59 I63 K66
Gene Ontology
Molecular Function
GO:0000149 SNARE binding
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0008429 phosphatidylethanolamine binding
GO:0031625 ubiquitin protein ligase binding
GO:0048487 beta-tubulin binding
GO:0050811 GABA receptor binding
GO:0051117 ATPase binding
Biological Process
GO:0000045 autophagosome assembly
GO:0000422 autophagy of mitochondrion
GO:0006891 intra-Golgi vesicle-mediated transport
GO:0006914 autophagy
GO:0006995 cellular response to nitrogen starvation
GO:0015031 protein transport
GO:0032781 positive regulation of ATP-dependent activity
GO:0070972 protein localization to endoplasmic reticulum
GO:0097352 autophagosome maturation
GO:1901799 negative regulation of proteasomal protein catabolic process
Cellular Component
GO:0000139 Golgi membrane
GO:0000421 autophagosome membrane
GO:0005737 cytoplasm
GO:0005776 autophagosome
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0016020 membrane
GO:0031410 cytoplasmic vesicle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6h8c, PDBe:6h8c, PDBj:6h8c
PDBsum6h8c
PubMed30990354
UniProtP60520|GBRL2_HUMAN Gamma-aminobutyric acid receptor-associated protein-like 2 (Gene Name=GABARAPL2)

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