Structure of PDB 6h7m Chain A

Receptor sequence
>6h7mA (length=291) Species: 9103 (Meleagris gallopavo) [Search protein sequence]
AAKVMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLV
VGLLVVPFGATLVVRGTWLWGSFLCELWTSLDVLCVTASIETLCVIAIDR
YLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQA
LKCYQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVYLRVYREAKEQIR
KIDRASKRKTSRVMAMKEHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNR
DLVPDWLFVAFNWLGYANSAMNPIIYCRSPDFRKAFKRLLA
3D structure
PDB6h7m Molecular basis for high-affinity agonist binding in GPCRs.
ChainA
Resolution2.76 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2CV A W181 A206 Y207 A210 W142 A167 Y168 A171
BS02 2CV A L78 K159 L39 K120
BS03 2CV A L289 K290 L222 K223
BS04 68H A D121 V122 F201 S211 S215 F306 F307 N329 D82 V83 F162 S172 S176 F239 F240 N262 PDBbind-CN: -logKd/Ki=7.80,Ki=15.8nM
BS05 2CV A R157 V160 R118 V121
BS06 2CV A A206 I209 A167 I170
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004935 adrenergic receptor activity
GO:0004940 beta1-adrenergic receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0045823 positive regulation of heart contraction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:6h7m, PDBe:6h7m, PDBj:6h7m
PDBsum6h7m
PubMed31072904
UniProtP07700|ADRB1_MELGA Beta-1 adrenergic receptor (Gene Name=ADRB1)

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