Structure of PDB 6h7e Chain A

Receptor sequence
>6h7eA (length=247) Species: 9606 (Homo sapiens) [Search protein sequence]
ASTERVLRAGRQLHRHLLATCPNLIRDRKYHLRLYRQCCSGRELVDGILA
LGHSRSQVVGICQVLLDEGALCHVKHDWAFQDRDAQFYRFPGPEPEPVEE
LAEAVALLSQRGPDALLTVALRKPPGQRTDEELDLIFEELLHIKAVAHLS
NSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGL
VTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRIIK
3D structure
PDB6h7e GEF regulatory domain
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CMP A F232 V251 V259 F268 G269 Q270 L271 A272 R279 A280 F174 V193 V201 F210 G211 Q212 L213 A214 R221 A222 BindingDB: Kd=4500nM
Gene Ontology
Biological Process
GO:0035556 intracellular signal transduction

View graph for
Biological Process
External links
PDB RCSB:6h7e, PDBe:6h7e, PDBj:6h7e
PDBsum6h7e
PubMed37438343
UniProtO95398|RPGF3_HUMAN Rap guanine nucleotide exchange factor 3 (Gene Name=RAPGEF3)

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