Structure of PDB 6h68 Chain A

Receptor sequence
>6h68A (length=1473) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
MDISKPVGSEITSVDFGILTAKEIRNLSAKQITNPTVLDNLGHPVSGGLY
DLALGAFLRNLCSTCGLDEKFCPGHQGHIELPVPCYNPLFFNQLYIYLRA
SCLFCHHFRLKSVEVHRYACKLRLLQYGLIDESYKLDEITLSSTLLNELK
SKRSEYVDMAIAKALSDGRTTERGSFTATVNDERKKLVHEFHKKLLSRGK
CDNCGMFSPKFRKDGFTKIFETALNEKQITNNRVKGTYILSTEVKNILDT
VFRKEQCVLQYVFHSRPNLSRKLVKADSFFMDVLVVPPTRFRLPSKLGEE
VHENSQNQLLSKVLTTSLLIRDLNDDLSKLQKDKVSLEDRRVIFSRLMNA
FVTIQNDVNAFIDSTKAQGRTSGKVPIPGVKQALEKKEGLFRKHMMGKRV
NYAARSVISPDPNIETNEIGVPPVFAVKLTYPEPVTAYNIAELRQAVING
PDKWPGATQIQNEDGSLVSLIGMSVEQRKALANQLLTPSSNVSTHTLNKK
VYRHIKNRDVVLMNRQPTLHKASMMGHKVRVLPNEKTLRLHYANTGAYNA
DFDGDEMNMHFPQNENARAEALNLANTDSQYLTPTSGSPVRGLIQDHISA
GVWLTSKDSFFTREQYQQYIYGCIRPEDGHTTRSKIVTLPPTIFKPYPLW
TGKQIITTVLLNVTPPDMPGINLISKNKIKNEYWGKGSLENEVLFKDGAL
LCGILDKSQYGASKYGIVHSLHEVYGPEVAAKVLSVLGRLFTNYITATAF
TCGMDDLRLTAEGNKWRTDILKTSVDTGREAAAEVTNLDKDTPADDPELL
KRLQEILRDNNKSGILDAVTSSKVNAITSQVVSKCVPDGTMKKFPCNSMQ
AMALSGAKGSNVNVSQIMCLLGQQALEGRRVPVMVSGKTLPSFKPYETDA
MAGGYVKGRFYSGIKPQEYYFHCMAGREGLIDTAVKTSRSGYLQRCLTKQ
LEGVHVSYDNSIRDADGTLVQFMYGGDAIDITKESHMTQFEFCLDNYYAL
LKKYNPSALIEHLDVESALKYSKKTLKYRKKHSKEPHYKQSVKYDPVLAK
YNPAKYLGSVSENFQDKLESFLDKNSKLFKSSDGVNEKKFRALMQLKYMR
SLINPGEAVGIIASQSVGEPSTQMTLNTFHFANVTLGIPRLREIVMTASA
AIKTPQMTLPIWNDVSDEQADTFCKSISKVLLSEVIDKVIVTETTAARSY
VIHMRFFDNNEYSEEYDVSKEELQNVISNQFIHLLEAAIVKEIKKQKNMN
KVQRDRQSAIISHHRFITKYNFDDESGKWCEFKLELAADTEKLLMVNIVE
EICRKSIIRQIPHIDRCVHPEPENGKRVLVTEGVNFQAMWDQEAFIDVDG
ITSNDVAAVLKTYGVEAARNTIVNEINNVFSRYAISVSFRHLDLIADMMT
RQGTYLAFNRQGMETSTSSFMKMSYETTCQFLTKAVLDNEREQLDSPSAR
IVVGKLNNVGTGSFDVLAKVPNA
3D structure
PDB6h68 Structural basis of RNA polymerase I stalling at UV light-induced DNA damage.
ChainA
Resolution4.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A S371 L373 H378 P593 D627 G630 D631 S295 L297 H302 P517 D551 G554 D555
BS02 dna A K442 K462 K463 R468 R475 R481 Q592 T1013 S1014 Y1018 E1616 T1617 K366 K386 K387 R392 R399 R405 Q516 T937 S938 Y942 E1426 T1427
BS03 dna A S1230 Q1601 S1149 Q1411
BS04 ZN A C65 H75 C65 H75
BS05 ZN A C102 C105 C102 C105
Gene Ontology
Molecular Function
GO:0001054 RNA polymerase I activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
GO:1990841 promoter-specific chromatin binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006360 transcription by RNA polymerase I
GO:0006361 transcription initiation at RNA polymerase I promoter
GO:0006362 transcription elongation by RNA polymerase I
GO:0006363 termination of RNA polymerase I transcription
GO:0042254 ribosome biogenesis
GO:0042790 nucleolar large rRNA transcription by RNA polymerase I
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005736 RNA polymerase I complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6h68, PDBe:6h68, PDBj:6h68
PDBsum6h68
PubMed30127008
UniProtP10964|RPA1_YEAST DNA-directed RNA polymerase I subunit RPA190 (Gene Name=RPA190)

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