Structure of PDB 6h4a Chain A

Receptor sequence
>6h4aA (length=358) Species: 9606 (Homo sapiens) [Search protein sequence]
AKDKVALLIGNMNYREHPKLKAPLVDVYELTNLLRQLDFKVVSLLDLTEY
EMRNAVDEFLLLLDKGVYGLLYYAGHGYENFGNSFMVPVDAPNPYRSENC
LCVQNILKLMQEKETGLNVFLLDMCRVTANIVFGYATCQEAFEIQHSGLA
NGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCHLTKGKQALEIRSSLSEK
RALTDPIQGTEYSAESLVRNLQWAKAHELPESMCLKFDCGVQIQLGFAAE
FSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSY
LVSKDLPKHCLYTRLSSLQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVNV
GKPLIAKL
3D structure
PDB6h4a An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient.
ChainA
Resolution2.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.22.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FNB A A345 L346 K379 V381 E390 N393 A394 E397 F398 L401 Q676 A6 L7 K40 V42 E51 N54 A55 E58 F59 L62 Q319 PDBbind-CN: -logKd/Ki=7.38,Kd=42nM
BindingDB: IC50=0.005nM
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6h4a, PDBe:6h4a, PDBj:6h4a
PDBsum6h4a
PubMed30692685
UniProtQ9UDY8|MALT1_HUMAN Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Gene Name=MALT1)

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