Structure of PDB 6h2j Chain A

Receptor sequence
>6h2jA (length=842) Species: 562 (Escherichia coli) [Search protein sequence]
NFIVLDKYIKAEPTGDSYQSESDLERELIQDLRNQGYEFISVKSQSAMLA
NVREQLQNLNGVVFNDSEWRRFTEQYLDNPSDGILDKTRKIHIDYICDFI
FDDERLENIYLIDKKNLMRNKVQIIQQFENRYDVTILVNGLPLVQIELKK
RGVAIREAFNQIHSENSLFKYLQLFVISNGTDTRYFANTTKRDKNSFDFT
MNWAKSDNTLIKDLKDFTATCFQKHTLLNVLVNYSVFDSSQTLLVMRPYQ
IAATERILWKIKSSFTAKNWSKPESGGYIWHTTGSGKTLTSFKAARLATE
LDFIDKVFFVVDRKDLDYQTMKEYQRFSPDSVNGSENTAGLKRNLDKDDN
KIIVTTIQKLNNLMKAESDLPVYNQQVVFIFDECHRSQFGEAQKNLKKKF
KRYYQFGFTGTPIFPENALGSETTASVFGRELHSYVITDAIRDEKVLKFK
VDYNDVRPQFKSLETETDEKKLSAAENQQAFLHPMRIQEITQYILNNFRQ
KTHRTFPGSKGFNAMLAVSSVDAAKAYYATFKRLQEEAANKSATYKPLRI
ATIFSFAAIGEISDETFDTSAMDSSAKEFLDAAIREYNSHFKTNFSTDSN
GFQNYYRDLAQRVKNQDIDLLIVVGMFLTGFDAPTLNTLFVDKNLRYHGL
MQAFSRTNRIYDATKTFGNIVTFRDLERSTIDAITLFGDKNTKNVVLEKS
YTEYMEGFTDAATGEAKRGFMTVVSELEQRFPDPTSIESEKEKKDFVKLF
GEYLRAENILQNYDEFATLKALQQIDLSDPVAVEKFKAEHYVDDEKFAEL
QTIRLPADRKIQDYRSAYNDIRDWQRTTDWDDVVFEVDLLKS
3D structure
PDB6h2j Crystal structure of a novel domain of the motor subunit of the Type I restriction enzyme EcoR124 involved in complex assembly and DNA binding.
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.21.3: type I site-specific deoxyribonuclease.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A K220 L270 R273 Q276 T309 G310 G312 K313 T314 D664 R688 R691 K194 L244 R247 Q250 T283 G284 G286 K287 T288 D632 R656 R659
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004519 endonuclease activity
GO:0005524 ATP binding
GO:0009035 type I site-specific deoxyribonuclease activity
Biological Process
GO:0006304 DNA modification
GO:0009307 DNA restriction-modification system

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Molecular Function
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Biological Process
External links
PDB RCSB:6h2j, PDBe:6h2j, PDBj:6h2j
PDBsum6h2j
PubMed30054276
UniProtP10486|T1R1_ECOLX Type I restriction enzyme EcoR124I/EcoR124II endonuclease subunit (Gene Name=hsdR)

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